Clarion Partners has acquired 245 First Street, a 305,000-square-foot office and life science complex in East Cambridge, MA, from an affiliate of Atlanta-based Jamestown Properties LP for $311.25 million, or $1,020 per square foot.

The property in Kendall Square across the Charles River from downtown Boston is comprised of a six-story, 134,175-square-foot Class A life science facility and a nine-story office tower of 170,714 square feet, built…